Effect of Formulation Method, Lipid Composition, and PEGylation on Vesicle Lamellarity: A Small-Angle Neutron Scattering Study

Liposomes are vesicles comprising a lipid membrane and aqueous core, and have found myriad applications in the biomedical field as therapeutics and in diagnostic assays. Liposome design requires careful choice of lipid composition and formulation method in order to produce populations with a defined unilamellar membrane structure. This is crucial in the development of liposome […]

Spontaneous Formation of Cushioned Model Membranes Promoted by an Intrinsically Disordered Protein

Histatin 5 is an intrinsically disordered, multifunctional, cationic, saliva protein known to act as the first line of defense against oral candidiasis caused by Candida albicans and belongs to the family of antimicrobial peptides. The mechanism at the base of its antifungal activity is still partially unknown. For this reason, understanding the interaction between Histatin […]

Apply for funding from Vinnova: Industrial pilot projects for utilisation of large-scale infrastructures for neutron and photon based techniques

  In this offer, we support project initiatives that build competence around industrial utilisation of advanced analytical techniques as those u at MAX IV and ESS. The proposals should be based on a need for at least one Swedish company and address verification regarding the suitability of the techniques to meet the need of the […]

Structure and composition of highly viscoelastic (α-CD)/anionic surfactant films investigated by neutron reflectivity

Understanding the surface rheological behavior of adsorbed films at the aqueous/air interface composed of sugars, surfactants, or complexes between them, is of great interest due to their relevance in different application areas ranging from food, medical diagnostics and oil recovery. Recently, we have found that α-cyclodextrin (α-CD)/anionic surfactant mixtures form films at the solution/air interface […]

Following protein dynamics in real time during crystallization

Diffraction from protein crystals remains the central pathway to high-quality protein structure determination, but a universal approach to crystallization has not been presented. This lack is linked to the underlying fundamental complexity of protein crystallization: proteins are nonspherical, flexible macromolecules with highly anisotropic interactions. Anisotropic sticky attraction can induce amorphous aggregation, and a better understanding […]

Local structure and vibrational dynamics of proton-conducting Ba2In2O5(H2O)x

Proton-conducting oxides are materials of huge interest for a variety of applications, such as electrolytes in membrane reactors or in proton-conducting fuel cells (PCFC) operating in the intermediate temperature range, T = 200 – 500°C. A limiting factor pertaining to the performance of present-day PCFC devices is a too low proton conductivity of the electrolyte […]

Producing matchout cholesterol for neutron scattering

The great advantage of using neutron scattering within the Life Sciences is not only the greater sensitivity towards hydrogen as compared to using X-rays as probe instead, but more importantly the ability to distinguish hydrogen from its heavier isotope deuterium.  This property enables highlighting different parts within a molecule or a molecular complex, and has […]

Understanding the structure of lipid sponge phase nanoparticle (L3-NPs) using small angle neutron scattering

Nonlamellar lipid liquid crystalline phases have many potential applications, such as for drug delivery, protein encapsulation or crystallization. Lipid liquid crystalline sponge phase (L3) has so far not been very much considered in these applications, in spite of apparent advantages in terms of its flexibility and capacity of forming large aqueous pores able to encapsulate […]

Tuning the alignment of nanocellulose using a magnetic field

Cellulose nanomaterials extracted from plants are very attractive due to their intrinsic optical and mechanical properties (e.g., high transparency, large elastic modulus, etc) and the potential novel applications that exploit these features. However, despite the extraordinary intrinsic properties of nanocelluloses at the nanoscopic level, the translation of the properties to the macroscopic level is not […]

Apply for funding via the new SAKURA Mobility Programme

To strengthen scientific collaboration between Sweden and Japan, the Swedish Research Council (VR) decided to fund and launch SAKURA, a new mobility programme focusing on neutron research and activities of ESS and J-PARC in particular. Personnel working at the two neutron sources as well as researchers affiliated with Swedish and Japanese universities are welcome to […]