Magdalena Almén

Liposomes are vesicles comprising a lipid membrane and aqueous core, and have found myriad applications in the biomedical field as therapeutics and in diagnostic assays. Liposome design requires careful choice of lipid composition and formulation method in order to produce populations with a defined unilamellar membrane structure. This is crucial in the development of liposome […]

As a result of decades of misuse of antibiotics, the number of bacteria resistant to commercially available antibiotics is increasing worldwide and is one of the major challenges facing global health. A unique drug-delivery system has been tested in vitro to understand its effect on bacteria. Antimicrobial peptides (AMPs) are host defense peptides present as […]

Histatin 5 is an intrinsically disordered, multifunctional, cationic, saliva protein known to act as the first line of defense against oral candidiasis caused by Candida albicans and belongs to the family of antimicrobial peptides. The mechanism at the base of its antifungal activity is still partially unknown. For this reason, understanding the interaction between Histatin […]

Understanding the surface rheological behavior of adsorbed films at the aqueous/air interface composed of sugars, surfactants, or complexes between them, is of great interest due to their relevance in different application areas ranging from food, medical diagnostics and oil recovery. Recently, we have found that α-cyclodextrin (α-CD)/anionic surfactant mixtures form films at the solution/air interface […]

Materials databases, high throughput computing, and data mining has emerged as powerful tools for screening and rapid prototyping of functional materials. Quantum magnetic systems, with often competing ground states and phases, are a challenge for ab initio modelling. In recent work at Nordita and KTH an important step forward was taken for predictive modeling of […]

Diffraction from protein crystals remains the central pathway to high-quality protein structure determination, but a universal approach to crystallization has not been presented. This lack is linked to the underlying fundamental complexity of protein crystallization: proteins are nonspherical, flexible macromolecules with highly anisotropic interactions. Anisotropic sticky attraction can induce amorphous aggregation, and a better understanding […]

Proton-conducting oxides are materials of huge interest for a variety of applications, such as electrolytes in membrane reactors or in proton-conducting fuel cells (PCFC) operating in the intermediate temperature range, T = 200 – 500°C. A limiting factor pertaining to the performance of present-day PCFC devices is a too low proton conductivity of the electrolyte […]

The great advantage of using neutron scattering within the Life Sciences is not only the greater sensitivity towards hydrogen as compared to using X-rays as probe instead, but more importantly the ability to distinguish hydrogen from its heavier isotope deuterium.  This property enables highlighting different parts within a molecule or a molecular complex, and has […]

Nonlamellar lipid liquid crystalline phases have many potential applications, such as for drug delivery, protein encapsulation or crystallization. Lipid liquid crystalline sponge phase (L3) has so far not been very much considered in these applications, in spite of apparent advantages in terms of its flexibility and capacity of forming large aqueous pores able to encapsulate […]

Cellulose nanomaterials extracted from plants are very attractive due to their intrinsic optical and mechanical properties (e.g., high transparency, large elastic modulus, etc) and the potential novel applications that exploit these features. However, despite the extraordinary intrinsic properties of nanocelluloses at the nanoscopic level, the translation of the properties to the macroscopic level is not […]