Why is it so that individuals with good cholesterol values develop cardiovascular disease, whilst other individuals with poor values remain healthy? Cholesterol and other fats are transported through the blood via specific transporters called lipoproteins. The most well-known are the so called “good” and “bad” cholesterol. Understanding these particles in structure and composition and the way they interact with artery wall is crucial in understanding this disease, the main killer of the West. Such knowledge would aid in improving diagnostic tools as well as in development of new drugs.