Structural biochemistry, 15 hp

KEMM25 Structural biochemistry, Lunds University

The course aims to give insights into protein structure, how it can be modelled and experimentally determined. We start by discussing the forces that drive proteins to fold into three-dimensional structures. Then we look at different databases and discuss homology modelling, i.e. how one can model a protein’s three-dimensional structure if one knows the structure of a sufficiently related protein. We also look at some of the most important experimental methods to determine the structure of proteins in different ways: X-ray crystallography, small-angle X-ray scattering and neutron crystallography. We describe how structural information on proteins can be used to develop better pharmaceuticals. The course includes site visits to Lund Protein Production Facility and MAX I
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