The Onset of Molecule-Spanning Dynamics in Heat Shock Protein Hsp90

by Felix Roosen-Runge Proteins are the biomacromolecular motors of life. While earlier accounts stressed the lock-key concept of protein function, a more complete understanding needs to take into account motions and molecular flexibility as ingredients how specific functions can be performed. In particular, larger conformational changes are known to reflect allosteric changes from active to […]

Interaction of a Histidine-Rich Antimicrobial Saliva Peptide with Model Cell Membranes: The Role of Histidines

by Amanda Eriksson Skog, Yuri Gerelli and Marie Skepö Here we present a continuation study of our previous paper, Spontaneous Formation of Cushioned Model Membranes Promoted by an Intrinsically Disordered Protein, in which we found that upon the interaction of Histatin 5 (Hst5) with a model lipid bilayer, a peptide cushion spontaneously forms underneath the […]

A Comprehensive Experimental Approach to Multifunctional Quantum Materials & their Physical Properties – Geometry and Physics in Condensed Matter

by Elisabetta Nocerino Symmetry-breaking phenomena underpin various intriguing physical properties in condensed matter such as magnetism [1,2,3,4] and superconductivity [5,6]. Understanding such fundamental properties holds significant importance for the development of cutting-edge technologies, including spintronics, quantum computing, and advanced magnetic materials, as well as foster innovation in energy-related applications [7]. The crystalline solid NaCr2O4 represents […]

A guide to spatially resolved phase and texture evaluation by diffraction contrast neutron imaging

The physical properties of structural as well as functional components are largely governed by the materials microstructure. In polycrystalline materials, the crystallographic phase and preferred grain orientation (texture) can dominate the physical properties. A range of microscopy and diffraction techniques are hence routinely used for their characterization, but are prone to miss local variations across […]

Coexisting curved and flat membranes

The complexity of cellular membranes is not only reflected by their wide molecular composition but also in the wide range of morphologies with coexisting high and low curvature regions. Very little is known about the nanostructure of curved membranes, due to limitations in experimental and simulation approaches. Even though curvature-induced microscopic phase separation has been […]

Webinar Registration: Structure Generation for MD Simulations of Soft Matter Systems

It is our great pleasure to invite you to an online launch event and workshop to showcase two new software workflows which will be of interest to the Small-angle Scattering and Disordered Materials communities. The development of these tools has been funded by the Ada Lovelace Centre and they are intended to offer users new […]

Advancements in Thermal Neutron Scattering Law Generation

The design of neutron systems, for example nuclear reactors and neutron sources, requires the usage of Monte-Carlo simulation software to predict the distributions of neutrons throughout the system. At low energies, the interactions of neutrons with a material is driven by interactions on the atomic and molecular scale and thus a proper description of this […]